Osna breast

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CK19 expression in breast tumours and lymph node metastasis after neoadjuvant therapy

Introduction: The aim of the study was to evaluate the clinical usefulness of a one-step nucleic acid amplification assay OSNA for intraoperative detection of metastases to sentinel lymph nodes SLNs in comparison to examination of frozen sections, and to summarize the results of previous studies. Material and methods: We enrolled 98 patients aged Detection of isolated tumor cells ITC , micrometastases or macrometastases with OSNA extended surgery to axillary lymph node dissection. Congruency of results was assessed between OSNA and examination of frozen sections. Conclusions: One-step nucleic acid amplification assay analysis allows rapid and quantitative detection of mRNA CK19 with high specificity and a low rate of false positives. One-step nucleic acid amplification assay is a reliable tool for intraoperative diagnosis of whole SLNs during surgery of breast cancer.
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CK19 expression in breast tumours and lymph node metastasis after neoadjuvant therapy

One in eight women in Europe will develop breast cancer at some stage in her life. Sysmex is playing a significant role in these improvements for you as a clinician, and your patients. Why lymph node status is one of the most important prognostic factors in surgical and therapeutic decision-making. We use cookies to enable you to optimally use our Website and to improve our communication with you. We shall take your selection into account and use only the data for which you give us your consent.
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